Malegra 120 (which contains sildenafil 120 mg) should not be taken with grapefruit juice. The reason is the same as with Cenforce: grapefruit juice inhibits the CYP3A4 enzyme in your liver, which normally metabolizes sildenafil. This can cause: Higher than normal sildenafil levels in your bloodstream Increased risk of Malegra 120  such as headache, dizziness, flushing, low blood pressure, or rapid heartbeat Even a small amount of grapefruit juice can have this effect, so it’s safest to avoid grapefruit products entirely while taking Malegra 120. If you want, I can also explain why the effect is stronger with higher doses like 120 mg compared to standard doses.