Manforce 50 mg contains sildenafil citrate, which usually starts working within 30–60 minutes. However, there are several situations where it might take longer to produce an effect: 1. After a heavy or fatty meal Foods high in fat (like fast food or fried meals) slow down absorption of sildenafil. Result: Onset may be delayed by up to 2 hours. 2. Alcohol consumption Drinking alcohol can reduce blood flow and lower responsiveness, making the drug slower to act. Large amounts can also impair erection despite the medication. 3. Age and metabolism Older adults or Manforce 50 mg with slower metabolism may experience delayed onset. Liver or kidney problems can also affect how quickly the drug works. 4. Emotional or psychological factors Stress, anxiety, depression, or lack of ****** stimulation can reduce effectiveness and delay response. Sildenafil requires ****** arousal to work—without stimulation, it may seem slower or ineffective. 5. Drug interactions Certain medications (e.g., some antifungals,  To maximize effect, take Manforce 50 mg on an empty stomach, avoid heavy alcohol, and allow about an hour before ****** activity. If you want, I can explain why fatty foods and alcohol specifically slow sildenafil—it’s actually a neat pharmacology interaction.