Cenforce 100 mg, which contains Sildenafil Citrate, the same active ingredient as Viagra. Here's why some people may experience headaches when taking Cenforce 100 mg: 1. Mechanism of Sildenafil Citrate Sildenafil works by inhibiting PDE5, an enzyme that usually breaks down cGMP (cyclic guanosine monophosphate), a molecule that causes smooth muscle relaxation and vasodilation (widening of blood vessels). This increases blood flow to the penis, which helps treat erectile dysfunction (ED). Blood Vessel Dilation: Sildenafil doesn’t just target the penile arteries; it can also affect other blood vessels in the body. The dilation of blood vessels throughout the body, including the blood vessels in the brain, can lead to headaches. This is because the increased blood flow can cause pressure changes in the brain’s blood vessels, leading to pain. Cenforce 100 mg Blood Flow & Pressure Changes When blood vessels dilate in the brain, it can cause a temporary increase in pressure, leading to tension or throbbing that is felt as a headache. This is particularly common in individuals who may already have a tendency to suffer from migraines or tension headaches, as the effects of blood vessel dilation can exacerbate those conditions. 3. Low Blood Pressure Sildenafil is a vasodilator, meaning it can also cause blood pressure to drop. This drop in blood pressure, though typically mild, can trigger headaches in some people, especially if their blood pressure is already low. When blood pressure drops too much, it can lead to symptoms like dizziness or a headache. This can be more pronounced if you are taking other medications that also lower blood pressure, or if you have a pre-existing condition that affects circulation.