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Tadarise 40 mg contains Tadalafil, which is a PDE5 inhibitor used to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). It works by increasing blood flow to the penis, helping to achieve and maintain an erection when sexually stimulated. However, it is dangerous to take Tadarise 40 mg (or any PDE5 inhibitor) with nitrates because of the potential for a severe drop in blood pressure.
Why is it Dangerous to Combine Tadarise 40 mg with Nitrates? Mechanism of Action: Tadalafil (Tadarise 40 mg) works by inhibiting the enzyme PDE5, which leads to the relaxation of the smooth muscles in the blood vessels of the penis, allowing more blood to flow into the area. Nitrates (like nitroglycerin and isosorbide dinitrate) are used to treat angina (chest pain) and other heart conditions. They work by increasing the production of nitric oxide, which causes the blood vessels to dilate (widen) and reduce the heart's workload. Both Tadalafil and Nitrates increase nitric oxide levels, leading to excessive vasodilation (widening of blood vessels).
When taken together, this effect can dramatically lower blood pressure, leading to symptoms like dizziness, fainting, heart attack, or stroke. Severe Drop in Blood Pressure: When taken together, Tadarise 40 mg (or any PDE5 inhibitor) and nitrates can cause hypotension (low blood pressure), which can be dangerous or even life-threatening. This can result in a sudden drop in blood pressure, making it difficult for the heart to pump blood effectively, potentially leading to severe dizziness, fainting, or heart failure in extreme cases.