Cenforce, a medication primarily used to treat erectile dysfunction (ED), contains sildenafil, which works by increasing blood flow to the penis. Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and other types, can sometimes cause sexual side effects such as reduced libido or erectile dysfunction. While Cenforce does not directly interact with antidepressants, caution should be exercised when combining the two, as both medications can affect sexual function. Moreover, certain antidepressants may influence the metabolism of sildenafil, potentially leading to altered drug effects. It's always advisable to consult with a healthcare provider before combining medications to ensure safety and avoid complications.