Flushing, which refers to redness and warmth in the skin, can be a side effect of Malegra FXT because of the medication's ingredients. Malegra FXT typically contains Sildenafil (commonly used for erectile dysfunction) and Fluoxetine (a selective serotonin reuptake inhibitor or SSRI, commonly used for depression and anxiety). Sildenafil, a component of Malegra FXT, is a phosphodiesterase type 5 (PDE5) inhibitor that helps relax blood vessels and increases blood flow to certain areas of the body, including the genital region. However, this increased blood flow can also lead to dilation of blood vessels in the skin, causing a flushed or red appearance, especially in the face and neck. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), can influence serotonin levels in the brain. Serotonin has a role in regulating blood vessels and can also contribute to vasodilation (expansion of blood vessels), which might lead to flushing in some people.

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